IMMM'II'AL FKKDlNd I'KKMM). 45 



Mandel and Oertel " made some experiments on man alon^ this 

 line, feeding first food ])oor in phosphorus and later food rich in 

 phosphorus, hut found no ell'eet upon the amount of organic phos- 

 phorus in the urine. They conclude that the organic phosphorus of 

 the urine is of endogenous origin. The inorganic phosphorus \vas 

 determined by uranium acetate tit ration, the solution was boiled 

 with hydrochloric acid and retitrated, t ho difference being the organic 

 phosphorus. 



Organic phosphoru- waa found in the human urine by Sotnits- 

 chewskv.'' Oertel/ usiiiLT the method of precipit at in.ir the inorganic 

 phosphorus with calcium chlorid in ammoniacal solution, found 

 organic phosphorus in the urine of seven men. 



Keller '' undertook >ome extensive experiments aloiiLT thi- line in 

 the case of infant-, and he concluded that the food did not influence 

 the amoiinl of organic phosphorus in the. urine. He starved himself 

 and found the amount of organic phosphorus eliminated the first 

 three day- \\a- Constant, uhile then- \\a- an increased elimination 

 the fourth day. This indicated that >ome highly organic phosphor- 

 i/e<l ti ue that i-. the lymphocytes were broken <lo\vn. 



Symmers -tudied thi- question in variou^ pathological Casefl 

 diseases of the nervous system, enteric fever, t uherculo-i-, diahctc-. 

 and lymphatic leucaemia and found laiire amounts of organ ie 

 ])ho-|)lioru- in the urine. 



In agreement \\ith nio-t invest JL r at"r- \\lm have >tudied phytin 

 and it- action on the |MM|V . Scofoin- ' and ( iiaco-a ' ; claim that pliytin 

 is principally eliminated in inorganic comhinat ion-. 



There i- no doubt that in pat hol<irical caSOB there i- con>i<lerabl 



organic combined phoaphonis eliminated, hul there is much doubt as to 



\\ he i her any pho-phoru- in the organic form is eliminated normally in 

 the 11 line. The method- \\hieh ha\e been em ployed t o -epa ra t e t he t \\ o 

 forms of pho>|)horu- are far from Satisfactory, The -liirht difference 

 between two iv-ult- obtained by different methods, which in nianv 

 cases \\oiild be counted afl <blplicate-. ha- been cla ed as <lue to the 

 pi-e-ence of organic- phosphorus. Moieo\cr. in this work, ether- 

 alcohol soluble phosphorus \\a- found in the urine. This is of little 

 -iirnificance. because a -olution of sodium hydrogen j)ho-phate yielded 

 an equivalent or greater amount of ether-alcohol soluble phosphorus 



N. Y. Univ. Bui. Med. Sci., 1901, 1 : 166. 



physi-.l. Cli.'in., 1880, ^:'_'l t. 

 Ml.i.L. 1898-9, 26 : 1 _':;. 

 dlbid., 1900. 



fj. Path. Bact., 1904-5, in : i:,;. H'7. 

 /Abs., Biochem. (Vntrbl., l!H)r,. .; : ooo. 



