AUTOPSY FINDINGS. 57 



Rabbit No. 4, fed inorganic phosphorus. 



Intestines: Apparently normal. 



Kidneys: Right, slight yellow color in cortex, pitted, congested; left, pitted over 

 external surface, slight congestion in medulla, very .-li-rht yellowish color in cortex. 

 Spleen: Apparently normal . 



Liver: Light color, lighter spots seen. Gall bladder apparently normal. 

 Stomach: Capillaries of fundus darkened apparently not post-mortem change. 

 Heart: Apparently normal. 

 Lungs: Left, apparently normal; right, lower half of lower l<>l> t > congested. 



linbbltx Xnx. .' tun/ H, nnrmalltj h <I. 



The autopsies showed that in the ca-es of the two normal rabbits, Xos. ~> and i. the 

 organs were apparently normal. The liver- had the normal dark-red color in contrast 

 with the pale liver- <! \..<. 1. '_', :;. and -I. 



Tin 1 autopsies showed that none of the experimental rabbits was 

 in a normal condition. The livers \\ere especially affected, bein^ 

 ]>ale and abnormal, and indicating an ez068B of fat. 



The relation of the liver to metabolism is a problem important to 

 both the phy-io|o-_:ist and the pathologist. For a loiuj time it has 

 been reeo'_:ni/ed that one .!' the functions of the liver is connected in 

 .some \\ay \\itli the destruction or removal of poison from the hlo<,d, 

 e-pc-cially such poison-. as are produced in, or absorbed from, the 

 alimentary canal. It \\ a> earl\ :/.ed that the destruction of 



the liver cells leads t.serioiis pisoiiiii'_r. Jiiul this w&B experimentally 

 demonstrated b\ Kck, \\ho e\<-luded the liver from the circulation 

 b\ making a direct communication between the portal vein and the 

 inferior vena ca\ ;i. an oj)"ration Unou n as " KcU listula." 



The ((uestioii of fatty degeneration has an ini|)ortnnt bearing from 

 the physioln-iral |Mi!it of \ie\\, for fa tt y de-eiieral ion is another 

 proof of the formation of fat from proteins. 1'Yom the investiga- 

 tions of Bauer" on do>_> and Leo on i'ro^ ur must admit that at 

 l-a-t in acute poivoniii'.: by pho-plmrus fatly degeneration takes 

 place \\ith the formation of fats from proteins. Still, invest i^ators 

 an not unanimous <>n this point, and Pflii^er'' especially has raised 

 objections to these experiments. 



The ideas of the fatty degeneration of protein in the old sense as 

 u-ed by these writers hav been changed by the work of Rosenfeld, d 

 etc.. who believe in the theory of fat transportation. 



In the ca-e of a phosphori/ed du;:. Mandel' has shown that lactic 

 acid disappears from the blood and urine when phlorhizin glycosuria 



Bid., 1871, 3 



*>Zts. phy-i.,1. Chem.. 1885,9:469. 

 Arch, iresam. IMiy.-i..! . \^.t\ 92,51:317. 

 *Erg-h. I'hysii:!.. Pi. I, Uiochemie, 1903,^:50. 

 eAmer. J. Physiol , Proc., 1905, l.i : 16. 



