DOURINE OB MALADIE DD COIT 35 



was greatly reduced, nervous and muscular control was resumed and the tenderness 

 over the loins finally disappeared. During this time ( the month of JanuarjO the 

 animal was kept under severe conditions in a pasture where the grass was scanty, 

 the snow deep and the cold intense. Since February 11th, when trypanosomata were 

 demonstrated in the vaginal mucus, the nervous symptoms have re-appeared, slowly 

 and gradually increasing in intensity, but have not yet reached the same degree as 

 before the blood letting. 



On June 1st there was great improvement in her condition (see photo plate XI). 

 The knuckling and ne.rvous inability can scarcely be observed. Trypanosomata at 

 this time were occasionally in vaginal blood. 



Throughout June, July and August, 1907, a great moderation was noticed in the 

 symptoms of neuro-muscular inco-ordination. The gait had become much steadier 

 and the knuckling of the fetlock joints was scarcely perceptible. Occasionally, foir 

 brief periods, there has been seen an intermittent ' tripping ' gait with swaying of 

 the hind-quarters from side to side, but on the whole, a steady, slow improvement ha3 

 been maintained up to the present date, November 15, 1907. 



THE BODY TEMPEEATUEE. 



Previous to Febnuary 15 the temperature was only occasionally recorded, and 

 was found to be between 100° and 101° F, Morning and evening temperatures have 

 been taken daily since February 16. From the fifth day after demonstration of 

 ti'y'panosomata in vaginal mucus, the temperature remained constantly between 101° 

 and 101:4° F., a variation of but half a degree, with almost an entire absence of 

 a normal regular daily rise and fall. On the 14th day there was a sudden elevation 

 lo 103.6° F, the respirations being shortened and pulsations increased to 60-65 per 

 minute. The nervous symptoms of the hindquarters and loins became more apparent. 

 The temperature gradually fell again to the neighbourhood of 101° F., the lowest 

 being 98° and the highest 102° F. 



THE LEUCOCYTE COUNT. (TABLES XII AXD XIII). 



Seven differential counts of the leucocytes of the blood of this animal have been 

 made during the three months of observation at intervals of 4, 8, 2, 40, 6 and 7 days. 

 Upon every occasion the relative percentages were found to be about normal, but at 

 the same time there was a decided absolute leucocytosis, all classes of cells being in- 

 creas^ld. This could easily be determined by a short examination of the stained 

 smear, and by the ratio of the red to the white cells, without actually making a 

 quantitative count. The bone-marrow type of cell, the polymorphonuclear neutro- 

 phyle, always prtedominated over the lymphoid cell, and this blood-picture has been 

 found in the other cases of Dourine at this station, in which the blood has been 

 studied, as evinced by nervous symptoms or intermittent (edematous swellings. An 

 opposite condition, namely, an absolute leucocytosis with a predomination of the 

 Lymphocyte type of cell, has been observed in those cases of Dourine in which the 

 disease is in a latent stage, where the materies morbi is lying dormant, or where 

 the animal is making a recovery, apparent or real. The Ilsemoglobin scale (Talquist) 

 registered 80-85 normal. 



For details of leucocyte counts and comparisons, see Table No. XII. 



9459— 3i 



