DEPARTMENT OF AGRICULTURE 



APPENDIX A. 



NATURALLY ACQUIRED DOURINE. 



Case Xo. 21. Mare. — Ovaries removed, September! 15, 1006. one to two years 

 after infection. Absence of signs of disease during winter of 1906-7. July 27, 28, 

 sexual excitement; covered by healthy stallion on each date. Genital examination 

 revealed a marked excoriation of mucous surfaces and external genitals, scars, loss 

 of pigment of the under surface of the tail, perinseum and L. pudendi. 



August 2. — Ulceration involving mucous membrane of vulva, and portions of the 

 vagina, these areas presenting numerous small vesicles and ulcers. 



August 10. — Lesions are disappearing. 



August 15. — Genitalia had resumed an almost normal condition. The mare 

 again appeared ' in heat,' and was covered by the healthy stallion. Submaxillary 

 and sublingual glands thickened and prominent. 



November 15. — No further, manifestation of disease. Genitalia appear normal. 

 General health and condition very good. 



Case No. 25 Mare. — 'A Remarkable Recovery(?).' — Admitted to Quarantine 

 Station February, 1906, in advanced stage of dourine. — Dr. S. Hadwen. 



December, 1906. — Great emaciation, dragging, paralytic gait. Complete loss of 

 co-ordinate locomotion. 



January-March, 1907. — The condition extremely severe. Death expected daily. 

 The animal was scarcely able to move and w^ould stay for days at a time in a corner 

 of the pasture, during intensely cold and blizzardy weather. 



April. — Slow, steady improvement. 



June-September. — Symptoms gradually disappearing. A great genenal improve- 

 ment. 



November 15. — The back is rather hollow. The quarters somewhat crouched. 

 Normal co-ordination. Mare is very active and in very fair health and condition. 



Note. — Othen examples of apparent recovery could be cited from milder cases, 

 but not from such a severe condition as above described. 



Case No. 73. Naturally Acquired Dourixe. — Probably infected by stallion 33 in 

 1905. A range mare, with young foal at foot. 



August 2, 1907. — Emaciation; genital discharge, scars and cicatrices. Crepita- 

 tion of joints. Loss of co-ordinate locomotion, 



August 4. — Profuse genital discharge. 



August 13. — Severe genital exacerbation. Papules, small vesicles and ulcers. 

 Raw mucous surfaces. Submaxillary lymphatics are enlariged. A secondary swell- 

 ing rapidly followed the subcutaneous injection of a test-serum. In the bloody 

 serosity of this swelling, developmental or involutive forms of trypanosomata were 

 discovered. 



November 15. — Increasing emaciation, diarrhoea and loss of co-ordination. 



Case No. 74. Naturally Acquired Dourine. (Plate XV.) — Gelding nisin..- 4 

 years. It is doubtful whether this animal was castrated as a yearling or a 2-yoar- 

 old. The animal has been running witli the above mare. No. 73. and tlie pair are 

 : hvays found together. 



