DOUR IN E OR MALADIE DU COIT 53 



July 29. — A complete loss of co-ordinate locomotion. The animal fre<iiiontly 

 falls to the ground when suddenly startled and is unable to stand without a voluntary 

 effort. (See photographs.) Trypanosomata have not been found in the blood. 



November 15. — Paralysis of tail. 



Case No. 75. — Naturally Acquired Dourine. — A range mare, with young sucking 

 foal at foot. 



September 25, 1907. — The whole of the visible genital mucous membrane is scat- 

 tered or mottled with copper-coloured haemorrhages. Trypanosomata present in fair 

 numbers. 



October 16. — ^Labia greatly tumefied, (edematous, pitting on pressure of the fingers 

 The perinseum in a similar condition. Hsemorrhagic patches have totally disappeared. 

 The mucous membrane is markedly (edematous with isolated infiltrated patches. Try- 

 panosomata are still present. 



November 25. — The whole of the genital mucous membrane is infiltrated. The 

 animal is in rather poor flesh, but not emaciated. Absence of nervous symptoms. 



Case No. 82. — Naturally acquired Dourine. — Kange mare, with young foal at 

 foot. 



September 25. — Infiltrated patches on vaginal mucosae. Tumefied vulva. 

 October 26. — Similar condition. Trypanosomata present. 



Noember 15. — Localized oedema on lower surface of abdomen. Poorly nourished 

 condition but not emaciated. Absence of nervous symptoms. 



Case No. 33. Naturally acquired Dourine. — Clydesdale stallion. Admitted to 

 quarantine station, July 21, 1906, with swollen sheath and testicles. — Dr. S. Hadwen). 



December, 1906, and January, 1907. — Paroxysmal and intermittent oedematoua 

 swellings of sheath, scrotum and lower surface of abdomen. Swellings would increase 

 for three or four days and then subside, with intermissions of 10-12 days. Numerous 

 examinations of the fluid of these swellings have been made. An immense number 

 of leucocytes were observed, 99 per cent of which were of the lymphocyte or mono- 

 nuclear variety, many intro and extra-cellular, spore-like bodies, and crescentic 

 forn:!«, thr> significance or identity of which I am at present unable to determine. An 

 indisputable stage or form of trypanosom© was not observed. 



February, 1907. — Continuous and moderate swelling of penis, sheath and scrotum 

 not extending to lower abdomen. 



April and May. — Steady increase in swellings, without intermissions, extending 

 on either side and beneath lower abdomen and thorax, involving the lower depend- 

 ent regions of the neck. 



June. — Enormous swellings with organization. Emaciation. Eupture of scrotum 

 and continuous discharge of thin pus. 



July — Apart from the weak, dragging gait, due to the swellings and emaciation, 

 neuro-muscular inco-ordination has not appeared. 



July 24. — ^Death, preceded by general paralysis. 



Jidy 24. — Autopsy. Extensive serous infiltrations of subcutaneous coanective 

 and muscular tissues. Anaemia. Flesh pale and yellow. Clear yellow fluid exudes 

 on section of muscles. The enormous swellings organized in a dlense, white fibrous 

 structure, on section, honeycombed with small serous cavities. 



The position of testicles could not be located by hand manipulation; on section 

 they were found embeddvxl in a fibrous mass 12-15 inches in thickness. After being 

 dissected out of this mass they were fovmd to weigh three pounds each. Scarcely any 

 recognizable testicular tissue remained. The under surface and sides of abdomen and 

 thorax presented a covering of the same dense fibrous character, 3-4 inches in thick- 

 ness. 



