520 



reference to the various conditions in wliich it may exist as acute, 

 chrome, and latent, show that the disease may assume several different 

 phases. Without losing sight for a moment of the fact that all of these 

 varied conditions are identical in their origin and in their essence, for 

 convenience of study we may divide glanders into three classes : Chronic 

 farcy, chronic glanders, and acute farcy glanders. 



The primary lesions in any form is a local point of eruption in which 

 we have a rapid prolification of the cell elements which make up the 

 animal tissue with formation of new connective tissue, with a crowd- 

 ing together of the elements until their own pressure on each other 

 cuts off the circulation and nutrition, and death takes place in them in 

 the form of ulceration or gangrene. Following this primary lesion we 

 have an extension of infection by means of those tissues immediately 

 surrounding the first infected spot, which is most suitable for tlie de- 

 velopment of simple inflammatory phenomena or the specific virus. 

 The primary symptoms are the result of inoculation developed at the 

 point of inoculation, but at a later time the virus is carried by means 

 of the blood vessels and lymphatic vessels to other parts* of the body 

 and becomes lodged at different places and develops m them ; again, 

 when the disease has existed in the latent form in the lungs of the 

 animal and the virus is wakened into action from any cause, we have 

 it carried to various parts of the body and developing in the most 

 favorable localities. The points of develoijmeut are most frequently 

 determined by the activity of the circulation and the effects of exterior 

 irritants. For example, if a horse which has been so slightly affected 

 with the virus of glanders that no symptoms are visible is exposed to 

 cold, rain, or sleet, or by the rubbing of the harness on the body and 

 the irritation of mud in the legs, the disease is apt to develop on the 

 exterior in the form of farcy, while a full-blooded horse which is em- 

 ployed at speed and has its lungs and respiratory tract gorged with 

 blood from the extreme use of these organs will develop glanders as 

 the local manifestation of the disease in the respiratory tract. 



Chronic farcy. — In farcy the symptoms commence by formation of 

 little nodes on the under surface of the skin, which rapidly infringe on 

 the tissues of the skin itself. These nodes, which are known as farcy 

 "buds" and farcy "buttons," are from the size of a bullet to the size 

 of a walnut. They are hot, sensitive to the touch, at first elastic and 

 afterwards become soft ; the tissue is destroyed, and infringing on the 

 substance of the skin the disease produces an ulcer, which is known as 

 a chancre. This ulcer is irregular in shape, with ragged edges which 

 overhang the sore j it has a gray, dirty bottom and the discharge is 

 sometimes thin and sometimes purulent ; in either case it is mixed with 

 a viscous, sticky, yellowish material like the white of an eg^ in con- 

 sistency, and like oUve oil in appearance. The discharge is almost diag- 

 nostic: it resembles somewhat the discharge which we have in greasy 

 heels and in certain attacks of lymphangitis, but to the expert the 



