525 



With good care, fjood food, and good surroundings and little work, 

 an animal affected with glanders may live for months or even years in 

 an apparent state of perfect health, but with the first deprivation of 

 food, with a few days of severe hard work, with exposure to cold or with 

 the attack of a simple fever or inflammatory trouble from other causes, 

 the latent seeds of the disease break out and develop the trouble again 

 in an acute form. 



At the post-mortem examination of an animal which has been de- 

 stroyed or has died of glanders we find evidences of the various lesions 

 which we have studied in the symptoms. In addition to this, wo find 

 tubercles similar to those which we have seen on the exterior through- 

 out the various organs of the body. Tubercles may be found in the 

 liver, in the spleen, and in the kidneys. We may have inflammation of 

 the periosteum of the bones, and we have excessive alterations in the 

 marrow in the interior of the bones themselves. Both of these con- 

 ditions during the life of the animal may have been the cau.se of the 

 lamenesses which were difficult to diagnose. 



In one case which came under the observation of the writer, a lame 

 horse was destroyed and- found to have a large abscess of the bone of 

 the arm, with old tubercles of the lungs. When an animal has died im- 

 mediately after an attack of a primary acute case of glanders, we find 

 small V-shaped spots of acute pneumonia in the lungs. If the animal 

 has made an apparent recovery from acute glanders, and in cases of 

 chronic farcy and chronic glanders no matter how few the external and 

 visible symptoms may have been, there is a deposit of tubercles- 

 small, hard, indurated nodes of new connective tissue to be found in the 

 lungs. When these have existed for some time we may find a deposit 

 of lime salts in them. These indurated tubercles retain the virus and 

 their power to give out contagion for almost an indefinite time, and pre- 

 dispose to the causes which we have studied as the common fiictors in 

 developing a chronic case into an acute case; that is, an inflammatory 

 process wakwiis up their vitality and produces a reinfection of the en- 

 tire animal. The blood of an animal suffering from chronic glanders 

 and farcy is not virulent and is unaltered, but during the attack of 

 acute glanders, while the animal has fever, the blood becomes virulent 

 and remains so for a few days. 



Treatme7it.—Fn\]y the entire list of drugs in the pharmacopoeia have 

 been tested in the treatment of.glanders. Good hygienic surroundings, 

 good food, with alteratives and tonics, frequently ameliorate the symp- 

 toms and often do so to such an extent that the animal would pass the 

 examination of any expert as a perfectly sound animal. But while in 

 this case the number of tubercles of the lungs, which are invariably 

 there, may be so few as not so cause sufQcient disturbance in the respi- 

 ration as to attract the attention of the examiner, they exist, and will 

 remain there almost indefinitely with the constant possibility of a return 

 of acute symptoms. 



