xiv CONTENTS 



CHAPTER VI ANAPHYLAXIS AND SERUM 



SICKNESS 55 



Serum sickness, 55 Anaphylaxis, 55 Symp- 

 toms of anaphylaxis, 56 Mechanism of anaphylaxis, 

 57 Examples of anaphylaxis, 58 Fatal cases of 

 anaphylaxis, 59 Besredka's test for anaphylaxis, 59 

 Precautions in administering sera, 61. 



CHAPTER VII VARIETIES OF SERA .... 62 



Normal serum, 62 Immune sera, 62 Types of 

 immune sera, 63 Action of antitoxic sera, 63 Ac- 

 tion of antibacterial sera, 64 Types of antibodies in 

 sera, 64. 



CHAPTER VIII PREPARATION OF IMMUNE 



SERA 65 



Care of horses, 66 Toxin production, 67 Im- 

 munizing the horses, 68 Bleeding, 69 Standardi- 

 zation, 70 Unit of antitoxin, 71 Tests applied to 

 antitoxin. 72 Method of refining antitoxin, 72. 



PART II 



SERUM THERAPY 



CHAPTER IX ANTITOXIC SERUM THERAPY 77 



History of diphtheria, 77 Mortality reduced by 

 antitoxin, 79 Prophylactic use of Diphtheria Anti- 

 toxin, 80 Therapeutic use of Diphtheria Antitoxin, 

 81 Dosage of antitoxin, 82 Value of large doses, 

 83 Single large dose, 84 Repeating the dose, 86 

 Difficult diagnosis, 87 The proper dose, 88 Early 

 administration, 89 Method of administration, 89 

 Value of intramuscular injections, 92 Futility of 

 subcutaneous route, 92 Treatment of late cases, 93 

 Tetanus, 94 Historic sketch of, 94 Tetanus tox- 

 in, 94 Tetanus and wounds, 95 Tetanus localities, 

 96 Tetanus Antitoxin in prophylaxis, 96 Reliabil- 

 ity of antitoxin, 97 Prophylactic dose, 98 Surgical 

 care, 98 Treatment of tetanus by antitoxin, 99 

 Mortality reduced by antitoxin, 100 Practical value 

 of antitoxin, 101 Dosage of Tetanus Antitoxin, 103 

 Supplementary treatment, 104 Method of intra- 

 spinal administration, 105. 



