56 MODERN BIOLOGIC THERAPEUSIS 



If, several months or years later, the patient 

 should be reinjected with horse serum, the 

 symptoms may be reproduced : may be more in- 

 tense and rapid; and may appear within 3 to 10 



Robert Koch (1843-1910). 



minutes or at least within an hour after injec- 

 tion. These rapidly appearing and intense 

 symptoms constitute the phenomenon of ana- 

 phylaxis, and consist of pruritus (manifested 

 by intense itching of the nose), sneezing, hy- 

 drorrhea, lacrimation, oppressed feeling, and 

 difficult respiration. Later, slight fever, ma- 



