60 MODERN BIOLOGIC THERAPEUSIS 



animal a small dose of the serum to be em- 

 ployed some time before the full dose was in- 

 jected, lie could prevent the development of 

 toxic symptoms. He applies the same princi- 



Elie Metchnikoff (1845-). 



pies and the same methods to the serum treat- 

 ment of disease in human patients (The Lan- 

 cet, August 16, 1913, p. 462). 



Thus, one or two drops (0.1 c.c.) of the se- 

 rum may first be injected subcutaneously and, 

 if no toxic symptoms (such as labored respira- 

 tion, cyanosis, unconsciousness, etc.) appear 



