SERUM THERAPY 103 



the preference over all others. The container 

 shown on page 107 has been especially devised 

 for administering the antitoxin intraspinally by 

 the gravity method. 



Dosage The following recommendations by 

 Park and Nicoll for the treatment of tetanus are 

 practically identical with those of Ashhurst and 

 John, and seem to be amply justified: "In 

 every case strongly suspected of being tetanus, 

 from 3,000 to 5,000 units of tetanus Antitoxin 

 should be given at the first possible moment in- 

 traspinally, slowly by gravity and always, if 

 possible, under an anesthetic. In order to in- 

 sure the quickest possible neutralization of all 

 toxins in the tissue fluids, it would seem advisa- 

 ble to give at the same time a dose of 10,000 or 

 15,000 units of antitoxin intravenously. It is 

 usually advisable to repeat the intraspinal in- 

 jection in 24 hours. Three or four days later, 

 a dose of 10,000 or 15,000 units given subcu- 

 taneously will insure a continuance of a highly 

 antitoxic condition during the next five days. 

 We do not believe there is any advantage in 

 giving larger amounts of antitoxin than those 

 indicated." 



When for various reasons Tetanus Antitoxin 



