SERUM THERAPY 119 



normal. The initial dose for children should be 

 100 c.c. The earlier in the disease that the 

 serum is employed the more favorable will be 

 the results : improvement being indicated by the 

 temperature, physical signs and other clinical 

 symptoms. The outfit illustrated on page 120 

 has been devised to furnish a convenient means 

 of administering the recommended large doses 

 of Antipneumococcus Serum and other antibac- 

 terial sera. 



Intravenous Administration The import- 

 ance of the intravenous method of administra- 

 tion, especially in severe cases of pneumonia, 

 cannot be too strongly emphasized. Dr. Rufus 

 Cole, Director of the Hospital of the Rockefel- 

 ler Institute, whose extensive experience makes 

 him a recognized authority in this country on 

 the treatment of pneumonia, employs 100 to 

 500 c.c. of this serum, diluted one-half with salt 

 solution, injected intravenously. In his pub- 

 lished report of a series of cases ( The Journal 

 A. M.A., August 30, 1913), Dr. Cole states: "The 

 conclusion seems justified, therefore, that one 

 large dose of serum given intravenously is suf- 

 ficient to sterilize the blood. The results ob- 

 tained, therefore, from the clinical and labora- 



