SERUM THERAPY 121 



has been devised for the successful specific treat- 

 ment of cases of acute lobar pneumonia." In 

 his report of 23 cases of pneumonia treated 

 with Antipneumococcus Serum (Collected Stud- 

 ies from the Bureau of Laboratories, New 

 York City Department of Health, 1913), Dr. W. 

 R. Williams states that as much as 300 c.c. of 

 the serum were injected intravenously with 

 good results. 



Results. Dr. Cole reports that all of the pa- 

 tients seemed to feel better following the injec- 

 tion of the serum and, in a number of cases, the 

 apparent lessening in the degree of intoxication 

 was very manifest. After most of the injec- 

 tions a reaction occurs ; the temperature usually 

 rises and then falls but does not necessarily re- 

 main low. In some cases the rise of tempera- 

 ture has been marked : in others, the rise of tem- 

 perature following an injection has been only a 

 degree or so. In all except fatal cases, the 

 serum had an ultimate favorable effect in lower- 

 ing the temperature and shortening the course 

 of the disease. 



Dr. Roland G. Freeman was one of the first 

 clinicians to use large doses of the serum. His 

 report (American Journal Diseases of Children, 



