122 MODERN BIOLOGIC THERAPEUSIS 



December, 1912) of a series of children, ranging 

 from 2 months to 3y 2 years of age, showed that 

 there was an important change in the appear- 

 ance of the child after the injection of the serum. 

 The children became brighter, took their feed- 

 ings better, and seemed much improved; and 

 there was a rapid reduction in temperature af- 

 ter the introduction of the serum. Dr. Freeman 

 states: "Serum injections apparently affect fa- 

 vorably the course of the disease and in most 

 cases there appears to be a better reaction on 

 the part of the child after serum injection than 

 before." 



In reviewing the work done on serum therapy 

 of 1'obar pneumonia, one sees a continuous pro- 

 gress in the efficiency of the methods of produc- 

 tion and administration of Antipneumococcus 

 Serum. In the earlier observations but little 

 attention was paid to potency of the serum or to 

 the characteristics of the bacteria employed in 

 its production. The doses administered and the 

 method of application were probably inadequate 

 in a majority of instances. Neufeld and 

 Haendel (Berliner klin. Wochenschr., 1912, 

 680) emphasized the importance of paying at- 

 tention to the strains of pneumococci used for 



