SERUM THERAPY 129 



blood infections. Burnham concludes that An- 

 tistreptococcus Serum is of great value, especi- 

 ally during the early stage when its bactericidal 

 powers are most pronounced; and, if given in 

 sufficient doses during the period of invasion, 

 will often change a systemic bacteriemia into 

 a localized infection. 



Locally Antistreptococcus Serum has been 

 used to a limited extent as a local application, 

 notably in cases of septic endometritis. The 

 uterus is packed with gauze saturated, with 

 serum and left for twenty-four hours, being re- 

 newed as often as symptoms demand. In a 

 large number of cases thus treated by Dr. Wil- 

 liam E. Studdiford at Bellevue Hospital, there 

 was a fall of temperature and pulse with 

 prompt subsidence of discharge and restoration 

 to normal condition. Those who have had per- 

 sonal experience are practically unanimous in 

 their belief of the superiority of this over other 

 forms of local treatment. 



The serum has been used as a spray for the 

 throat in cases of streptococcic sore throat. 

 Spiess (Deutsch. med. Wochensch., 1912, xxx- 

 vin, 207) used it with advantage in the form of 

 a paste as a direct application to the tonsils, and 



