130 MODERN BIOLOGIC THERAPEUSIS 



Sexton (Archives of Pediatrics, 1913, xxx, 81) 

 has found it very efficient when applied as a 

 moist dressing to infected wounds. It appears 

 that a more extensive trial in this local manner 

 would be desirable as in many cases the serum 

 would thus be brought into direct contact with 

 the infecting bacteria. 



Judging from what occurs in experimental 

 animals, Antistreptococcus Serum should be an 

 efficient prophylactic agent against streptococ- 

 cic infections in man, and its use before cer- 

 tain operations such as those about the mouth, 

 after which streptococcus infections are liable 

 to occur seems justifiable. 



Dosage of Serum The dosage of this serum 

 as laid down by the foreign investigators should 

 be 200 c.c., followed in twelve to twenty-four 

 hours by one-half this dose. The method em- 

 ployed and recommended by the New York City 

 Department of Health is to inject 200 c.c. for the 

 initial dose in adults, the injection preferably 

 being given intravenously. If given subcu- 

 taneously, 100 c.c. are injected in either side of 

 the anterior abdominal wall. The initial dose is 

 followed in twelve to twenty-four hours by 100 

 c.c. For infants, the initial dose is usually 100 



