132 MODERN BIOLOGIC THERAPEUSIS 



days. On this account the serum should be ad- 

 ministered intravenously, especially in urgent 

 cases. 



ANTIGONOCOCCUS SERUM. 



The unfavorable criticism accorded Antigono- 

 coccus Serum has been due to two factors: (1) 

 Improper use of the serum, and (2) small dos- 

 age. In the serum of animals immunized against 

 gonococci, Torrey has demonstrated agglutin- 

 ins, precipitins, and bactericidal and comple- 

 ment fixing bodies. Rogers and Torrey (The 

 Journal A. M. A., 1907, XLIX, 918) first intro- 

 duced a polyvalent serum prepared by immun- 

 izing rams against several strains of gonococci. 



Clinical Reports A number of clinicians 

 have reported the successful use of the serum in 

 gonococcus infections of the joints and tendon 

 sheaths, and in epididymitis. In most of the 

 cases reported, the serum has been used subcu- 

 taneously. It is generally conceded that the 

 serum has produced no beneficial effects in in- 

 fections of the mucous membranes. The pro- 

 duct was originally marketed in 2 c.c. doses, and 

 all the reports until recently have been on the 

 use of this small dosage; and the results have 

 usually been disappointing. Naturally, good 



