134 MODERN BIOLOGIC THERAPEUSIS 



circulation, including arthritis and endocardi- 

 tis. The serum may also be well used in acute 

 uretliritis to prevent the spread of the infection 

 into these other organs, but large doses are 

 necessary. 



Dosage Never less than 10 c.c. should be 

 given at a dose ; and to secure the most satisfac- 

 tory and at the same time the quickest results 

 the serum is best administered intravenously in 

 doses of 50 to 100 c.c. In malignant cases the 

 initial dose may be 100 to 200 c.c. If the physi- 

 cian prefers not to use the intravenous route, 

 the serum may be injected subcutaneously into 

 the anterior wall of the abdomen 100 c.c. being- 

 injected on either side. The doses are usually 

 repeated at intervals of 24 to 48 hours; but, in 

 toxic cases, the serum may be given every 12 

 to 24 hours. The clinical symptoms must in- 

 evitably be the guide for repeating the injec- 

 tions that is, if the patient responds to the 

 first dose and shows improvement, the second 

 dose may not be required until a day or two 

 later. By using a large initial dose, the infec- 

 tion is more quickly brought under control; 

 fewer doses are necessary; and the expense of 

 the treatment thereby lessened. 



