136 MODERN BIOLOGIC THERAPEUSIS 



tis is shown by the almost immediate relief of 

 pain. At times within two or three hours there 

 is considerable amelioration, and patients who 

 have been unable to sleep on account of pain 

 enjoy a refreshing rest. The pain to pressure 

 is also less marked and the acute inflammatory 

 swelling and edema rapidly disappear within 

 24 to 36 hours. 



ANTIMENINGOCOCCUS SERUM 



Historic Epidemic cerebrospinal meningitis 

 is a comparatively modern disease. Its distinct 

 recognition dates back no further than 1805 

 when Viesseux in Geneva pointed it out as a 

 separate disease, although there can be little 

 doubt that it existed previously. Symptoms 

 that almost conclusively point to this disease 

 are described in the histories of the great epi- 

 demics of Europe from the thirteenth century 

 on. 



Prevalence Cerebrospinal meningitis is an 

 acute infectious disease with a characteristic lo- 

 cal lesion in the meninges and tissues of the 

 brain and spinal cord. America is peculiarly 

 the home of this disease, and it is difficult in 

 studying the literature to account for this fact. 



