148 MODERN BIOLOGIC THERAPEUSIS 



doubt that Normal Horse Serum administered 

 subcutaneously or intravenously is a valuable 

 hemostatic in cases of hemorrhage. Also that 

 it may be a valuable prophylactic agent before 

 operation in individuals with a hemorrhagic 

 tendency, but we are as yet ignorant of its mode 

 of action. It has been used fairly extensively 

 and the accumulated experience indicates that 

 there is little, if any, danger of producing in- 

 travascular clotting. 



Indications Normal Horse Serum is used in 

 the treatment of so-called hemorrhagic diseases 

 including hemophilia, hemophilia neonatorum, 

 purpura and hematuria diseases in which the 

 tendency to bleed is dependent upon some dis- 

 turbance of the factors in the coagulation of the 

 blood. Normal Horse Serum is also used for 

 other forms of hemorrhage epistaxis, metror- 

 rhagia, hemorrhage from wounds and fractures 

 and, in connection with surgical operations, to 

 prevent postoperative hemorrhage. The long 

 list of diseases with which hemorrhage may be 

 associated justifies the large field in which 

 Normal Horse Serum may be applied. 



Hemophilia may be defined as a hemorrhagic 

 diathesis, hereditary or otherwise, character- 



