SERUM THERAPY 151 



DOSAGE AND ADMINISTRATION 



Iii hemophilia, the usual dosage is 10 to 20 c.c. 

 given intravenously. It is apparently most 

 prompt in its action and most efficacious when 

 given intravenously. Sometimes a single dose 

 suffices to stop the hemorrhage. In cases of 

 continued bleeding, the dose may be repeated 

 at intervals of two to six hours or even longer, 

 depending upon the urgency of the indications. 

 For hemophilia neonatorum and hemorrhage 

 from the umbilical cord, 10 c.c. should be given 

 subcutaneously and repeated three times daily 

 or even every two hours. As a preventive for 

 postoperative hemorrhage, 20 c.c. are admin- 

 istered subcutaneously on the day preceding the 

 operation. 



In severe epistaxis, the nares may be plugged 

 with gauze dipped in the serum ; and in metror- 

 rhagia, the uterus and vagina are tamponed with 

 sterile gauze saturated in the Normal Horse 

 Serum. For topical application to wounds, 

 sterile gauze saturated with the serum may be 

 applied freely to oozing surfaces. 



