212 MODERN BIOLOGIC THERAPEUSIS 



About 12,000 men have been inoculated with the 

 mixed vaccine; and the results recorded in five 

 naval hospitals in Japan during the period 1909 

 to 1911, after the introduction of inoculation 

 with the mixed vaccine, show that adequate pro- 

 tection can be attained against the typhoid and 

 paratyphoid bacilli. 



Typhoid vaccination is not compulsory in the 

 Italian army, but over 7,000 were vaccinated in 

 1913. The antityphoid vaccine was mixed with 

 antiparatyphoid vaccine and the morbidity 

 after one injection was 4.4 per thousand, after 

 two, only 2.7, and after three injections, 0.3 per 

 thousand; while the non-vaccinated developed 

 typhoid or paratyphoid in 35.3 per thousand 

 with a mortality of 7.1 per thousand. 



DOSAGE OF COMBINED TYPHOID VACCINE 



The combined vaccine is administered in 

 three doses at intervals of seven to ten days, and 

 the reactions resemble those which follow the 

 use of plain typhoid vaccine. The initial dose 

 contains 250 million of each of the paratyphoid 

 bacilli "A" and "B", and 500 million of the 

 typhoid bacilli. The second and third doses both 

 contain double these amounts. 



