VACCINES IN PROPHYLAXIS OF DISEASE 223 



Vaccines has been done by Russians, led by 

 Gabritschewsy (Berliner klin. Wochensch., 1907, 

 XLIV, 556). Nearly all of the published ac- 

 counts are in Russian, so that the method has 

 attracted comparatively little attention of the 

 profession generally. More than 50,000 cases 

 are on record which have been successfully pro- 

 tected with the Streptococcus Vaccines, which 

 are prepared from streptococci isolated only 

 from cases of scarlet fever. It is claimed that 

 after three injections of the vaccine and usually 

 after two, a complete immunity is established 

 against scarlet fever, lasting probably about a 

 year and a half. The vaccination is contrain- 

 dicated in very young infants or in persons 

 greatly prostrated from any cause, such as 

 nephritis. 



Dosage The injections are given at intervals 

 of seven days. The first dose contains 250 mil- 

 lion killed bacteria; the second dose contains 

 500 million ; and the third dose 1,000 million. 



Reaction In most cases there appears at 

 the site of the primary injection, about 24 hours 

 after it is given, an area of redness and in- 

 filtration, somewhat painful and tender and 

 lasting a few days. With this is also assooi 



