224 MODERN BIOLOGIC THERAPEUSIS 



ated a slight rise in temperature. In about 10 

 to 15 per cent of the cases, an erythematous 

 eruption resembling scarlet fever appears at 

 the site of injection and sometimes extends over 

 most of the body; in which case there may be 

 associated angina, swelling of the lymph glands 

 and strawberry tongue. Reactions after the 

 second and third injections are less severe. 



Results Statistics furnished by the Russian 

 workers appear to speak very strongly of the 

 value of the prophylactic vaccination. Smir- 

 noff used the vaccine in thirteen small villages in 

 Russia where the sanitary conditions were very 

 poor and where there was no possibility of 

 quarantine. He vaccinated 455 people and 

 every one who received three full injections was 

 protected against the disease. In villages with- 

 out vaccination, 20 per cent contracted the dis- 

 ease and 11 per cent died; in villages with vac- 

 cination, 3 per cent contracted the disease and 

 none died. In an epidemic in Kharkov, 610 

 people were inoculated by Yemelyarioff and not 

 a single person contracted the disease. Zelikin 

 used the vaccine in country practice during a 

 severe epidemic and, among 613 people who re- 

 ceived only two injections of the vaccine, none 



