226 MODERN BIOLOGIC THERAPEUSIS 



Immunity At the end of the epidemic, So- 

 phian and Black carried out experimental pro- 

 phylactic vaccinations on eleven students in the 

 Southwestern Medical College using varying 

 doses of Meningococcus Vaccine. Subsequently 

 Black carried out complement fixation tests on 

 eight of the original students, and was able to 

 demonstrate immunity at the end of one year as 

 a result of the vaccination. More recently ( The 

 Journal A. M. A., December 12, 1914), Black 

 carried out complement fixation tests on the 

 serum of seven of the vaccinated students and 

 showed that a high degree of immunity still per- 

 sisted at the end of two years after the date of 

 vaccination. It seems a justifiable conclusion 

 that persons prophylactically vaccinated may 

 safely consider themselves immune for at least 

 two years. 



Dosage The dosage established by Sophian 

 and Black consists of 500 million killed menin- 

 gococci as the first dose; 1,000 million for the 

 second and third doses, the injections being 

 given at 7 to 10-day intervals. 



Reaction The local reaction is very much 

 the same as obtains after injections of other 

 bacterial vaccines, notably Typhoid Vaccine. A 



