VACCINES IN PROPHYLAXIS OF DISEASE 227 



few hours after injection there are redness, 

 swelling and tenderness at the point of inocula- 

 tion. Some subjects react more severely than 

 others. Pain in any marked degree rarely lasts 

 more than a few hours. General constitutional 

 symptoms are frequently missing. Most often 

 the patient complains of moderate headache and 

 general malaise, and the temperature rises from 

 one to three degrees. Sometimes, however, the 

 temperature may rise to 104 degrees F., and the 

 patient may suffer from nausea and have bodily 

 pain, and may vomit. 



Results During 1913, Texas had a moderate 

 amount of meningitis, though it was really free 

 from an epidemic. Vaccine was used in quite a 

 considerable number of people. It was em- 

 ployed both in civil communities and in institu- 

 tions. According to Sophian, there were at 

 least 5,000 people vaccinated and he could 

 find no record of meningitis developing among 

 those vaccinated. In the same year, quite severe 

 epidemics occurred in Tennessee, Arkansas and 

 Nebraska. Prophylactic vaccination was lib- 

 erally employed in six communities and, as far 

 as can be learned from reports, the vaccina- 

 tions were successful. Major Wadham of the 



