VACCINES IN PROPHYLAXIS OF DISEASE 231 



other seven, the treatment was incomplete but 

 four of these had milder attacks. Lowdermilk 

 reports 19 cases, with successful results in 16. 

 Koessler has treated 41 hay fever patients by 

 active immunization with Pollen Vaccine and 

 reports four completely cured ; 29 markedly im- 

 proved subjectively and objectively ; 5 were sub- 

 jectively improved, while the remaining 3 were 

 not affected. Oppenheimer and Gottlieb treated 

 1 1 patients before and during the hay fever sea- 

 son : altogether there were 5 cures, and marked 

 improvement occurred in 4 cases ; while 2 of the 

 cases showed no improvement. 



Marked improvement consists in later, milder 

 and shorter attacks; in the possibility of re- 

 maining in town and at work for the first time 

 in years ; and in a diminution or disappearance 

 of the troublesome cough and constitutional 

 symptoms. 



POLLEN VACCINE 



Description of Vaccine While the results 

 obtained by the above-mentioned investigators 

 have demonstrated the efficiency of Pollen Vac- 

 cine, yet their work has also shown that watery 

 extracts of pollen are unstable and rapidly de- 

 teriorate, losing their potency after about three 



