236 MODERN BIOLOGIC THERAPEUSIS 



in the following spring, the active immunization 

 had to be repeated in order to protect the in- 

 dividual from an attack during the next hay 

 fever season. This emphasizes the fact that 

 patients must return each year for several 

 years, if the prophylactic treatment is to have 

 a permanent influence on their susceptibility to 

 hay fever.. 



Some General Principles (1) Patients with 

 marked constitutional disturbances including 

 asthma, apparently derive greater benefit from 

 the prophylactic inoculations than patients with 

 slight and local symptoms. (2) Age makes no 

 difference in the benefit derived from the pro- 

 phylactic treatment. 



Treatment during Attack While it is most 

 desirable and recommended by all workers that 

 the inoculations be strictly prophylactic that 

 is, that they be given prior to the onset of the 

 hay fever season yet several investigators 

 have used the Pollen Vaccine for treating pa- 

 tients during an actual attack of hay fever. 

 Thus, Lowdermilk treated 16 patients after the 

 onset of the actual attack and 13 of them were 

 cured; the 3 not benefited all began treatment 

 more than a month after the onset of symptoms. 



