240 MODERN BIOLOGIC THERAPEUSIS 



clusively that, with correct dosage, whatever 

 force it had was more theoretical than real, and 

 that the most important evidence must come 

 from actual experience rather than from labora- 

 tory experiment. Pfeiffer and Friedberger dis- 

 proved the presence of a negative phase in lab- 

 oratory tests on guinea-pigs, as did Leishman 

 in 100 patients at the Baring Asylum. Wright 

 himself since 1909 -has receded to a very great 

 degree from his position concerning a negative 

 phase. 



Application The enthusiastic supporters of 

 therapeutic inoculation stretch the possible ap- 

 plication of bacterial vaccines to cover the treat- 

 ment for all diseases ; and they attempt to show 

 that the introduction of large numbers of ex- 

 traneous bacteria stimulates the natural im- 

 munizing processes to greater activity, thus ar- 

 tificially fostering the slow process of naturally 

 acquired immunity. Such enthusiasts lose sight 

 of the fact that there is no common mechanism 

 of immunization. The process differs not only 

 according to the type of infecting agent, but also 

 according to its virulence; and failure of the 

 infected host to respond by effective defensive 

 processes, also plays an important part. No 



