242 MODERN BIOLOGIC THERAPEUSIS 



any sign of general or focal reaction is pro- 

 duced and so long as steady progress is main- 

 tained. 



CLINICAL EVIDENCE REGARDING THERAPEUTIC 

 INOCULATION 



If improvement occurs regularly after a given 

 treatment, when used in cases in which improve- 

 ment does not usually occur so quickly, we have 

 some reason to believe that the measure has 

 therapeutic value. In any individual case, the 

 question as to whether such improvement oc- 

 curred is necessarily decided by the judgment 

 of the physician whose conclusions are based in 

 turn on his experience in other similar cases and 

 on his accuracy of observation. There are, 

 however, so many undeterminable and recog- 

 nized factors which influence the outcome of any 

 individual case that case reports covering a 

 small number of observations offer very little 

 assistance in determining the value of a method, 

 particularly when we remember that there is 

 always a tendency to report favorable cases and 

 to allow the unfavorable to pass unnoticed. 

 Only when large groups of cases accompanied 

 by adequate control cases are available, can 



