244 MODERN BIOLOGIC THERAPEUSIS 



stated that the more closely the case approaches 

 a strictly localized infection, the more likely is 

 it to prove amenable to vaccine treatment. 



According to Sondern of New York City, vac- 

 cine therapy in acute general infections is still 

 open to question from a theoretical standpoint, 

 and should be considered as purely experiment- 

 al ; but bacterial vaccines have proved of value 

 in cases of localized and chronic infections. 



REACTIONS FOLLOWING VACCINES 



The inoculation of specific bacterial vaccines 

 into an individual suffering from an infectious 

 disease is followed by clinical changes in the 

 disease which constitute what is known as a " re- 

 action. " These changes may be: (1) Local, at 

 the site of inoculation, including edema and 

 erythema; (2) Focal, at the site of localization 

 of the infection, such as increased pain and 

 swelling in joints; (3) General, including fever, 

 leukocytosis, malaise and headache. The clini- 

 cal reactions have been extensively employed in 

 diagnosis and have proved of service in the reg- 

 ulation of the dose and interval of the inocula- 

 tions in the treatment of diseases by active im- 

 munization. 



