VACCINES IN TREATMENT OF DISEASE 257 



one that, in treating any skin disease with bac- 

 terial vaccines, the initial dose must be small. 



ACNE 



Acne may be divided into two classes; the 

 non-pustular variety in which comedones are 

 the predominating lesions; and the pustular 

 type. It is now generally accepted that the acne 

 bacillus is the direct cause of all cases of acne. 

 In the pustular variety of this disease, the sta- 

 phylococcus is the chief complicating factor. 

 In the vaccine treatment of the non-pustular 

 type of acne, the plain Acne Vaccine is indi- 

 cated ; while the pustular variety is best treated 

 with a combined vaccine containing the staphy- 

 lococcus as well as the acne bacillus. 



Vaccine therapy is not in itself always suffi- 

 cient to correct this condition. While it is a 

 striking advance over the older methods of 

 treatment, nevertheless it must be combined 

 with proper surgical and medical measures in 

 order to obtain good results. When Acne Vac- 

 cine was first used, too large doses were usually 

 given; and the injections were followed by the 

 appearance of new lesions. There is no rule 

 that can be made in regard to dosage which will 



