VACCINES IN TREATMENT OF DISEASE 261 



favorable results. There are some cases, how- 

 ever, of furunculosis that do not respond readi- 

 ly to vaccine treatment regardless of the na- 

 ture of the vaccine. Such failures may be due 

 in some instances to error in the size or interval 

 of the inoculations. Boils are almost always 

 caused by the staphylococcus aureus; although 

 some cases are seen in which both the albus and 

 aureus type are present, and some in which the 

 staphylococcus albus alone is found. There- 

 fore, in treating this condition it is best to use a 

 Staphylococcus Vaccine containing both the al- 

 bus and the aureus variety. 



As in other conditions amenable to vaccine 

 therapy, the question of dosage and interval be- 

 tween injections is of the utmost importance in 

 treating furunculosis. Although no set rule can 

 be given in regard to the administration of the 

 vaccine, the best and safest procedure is to be- 

 gin with a rather small dose 50 to 100 million 

 in adults and about 25 million for children the 

 injections being given usually at 5-day inter- 

 vals. Using the local reaction and clinical 

 course of the disease as a guide, the dosage may 

 be increased until 500 to 1,000 million are given 

 to an adult and 100 to 250 million to children. 



