264 MODERN BIOLOGIC THERAPEUSIS 



combined vaccine may be administered in initial 

 doses of 100 million staphylococci and 25 mil- 

 lion streptococci. 



ERYSIPELAS 



In erysipelas, several workers have noted 

 less frequent recurrences in cases treated with 

 vaccine, but they were unable to see any limita- 

 tion of the disease. An analysis of the clinical 

 course of 800 cases of erysipelas under the care 

 of Erdman shows that the duration of the dis- 

 ease was not lessened; the mortality remained 

 at the same level, and there was no immunity 

 guaranteed against recurrences. In cases with 

 a minimal degree of constitutional disturbances, 

 vaccines may be used during the attack and as a 

 prophylactic against recurrences; but a suc- 

 cessful outcome from the attack cannot be regu- 

 larly attained. 



If vaccine therapy is used in these conditions, 

 it is important to employ a polyvalent vaccine 

 because of the wide diversity of streptococcus 

 strains. The initial dose of Streptococcus Vac- 

 cine should be small, 25 to 50 million, the in- 

 jections being given every second or third day; 

 but, if no improvement follows after 24 hours, 

 another dose may then be given. In erysipelas 



