272 MODERN BIOLOGIC THERAPEUSIS 



terior urethritis (gleet), epididymitis, and gon- 

 orrheal rheumatism, a combined vaccine con- 

 taining the gonococcus, staphylococcus, strep- 

 tococcus and B. coli is usually required in order 

 to combat the mixed infection. 



DOSAGE OF GONOCOCCUS VACCINES 



The dosage recommended in gonococcus in- 

 fections varies greatly from one million to 

 1,000 million being advised by different workers. 

 From 5 to 50 million is a good initial dose, which 

 may be increased up to 1200 million or more. A 

 combined vaccine is used in initial doses of 75 

 million gonococci, 50 million B. coli, 75 million 

 streptococci and 300 million staphylococci, until 

 15 or 20 times these amounts are given. The in- 

 tervals between the doses vary from two to sev- 

 en days. 



REACTION 



The degree of reaction allowable must be de- 

 termined by a study of the individual case, but 

 in general it is safe to restrict the dosage so that 

 the clinical changes in the patient immediately 

 following the inoculation are relatively slight. 

 In the treatment of arthritis and epididymitis. 

 Bruck believes that a slight temperature reac- 



