VACCINES IN TREATMENT OF DISEASE 277 



Vaccine Treatment In treating or immuniz- 

 ing against coryza or common colds of non-epi- 

 demic variety, a combined vaccine containing the 

 micrococcus catarrhalis, Friedlander bacillus, 

 pneumococcus, streptococcus and staphylococ- 

 cus will best fulfill the indications. If the clini- 

 cal symptoms or bacteriologic examination point 

 to true influenza or "La Grippe" of the epi- 

 demic form, the combined vaccine should con- 

 tain, in addition to the above-named organisms, 

 the influenza bacillus. The clinical results of 

 the use of such combined vaccines have been fa- 

 vorably reported (Stevenson: Indiana State 

 Medical Association Journal, June, 1913). One 

 characteristic feature of the vaccine treatment 

 is a general improvement that is induced before 

 the local infection shows much change. 



Dosage For prophylaxis, four doses are giv- 

 en at 3-day intervals. The initial dose should 

 not exceed 25 million of each variety of bacteria 

 mentioned above, and the subsequent doses may 

 consist of multiples of the first dose. For treat- 

 ment, the initial dose, containing 25 million of 

 each variety of bacteria, is usually followed on 

 the second day by double that dose ; and the dos- 

 age may then be increased every 3 or 5 days ac- 



