278 MODERN BIOLOGIC THERAPEUSIS 



cording to indications, until all symptoms of the 

 disease have disappeared. If marked local or 

 constitutional reaction follows any dose, the 

 subsequent dose should not be increased. 



PNEUMONIA 



The pioneer in the work of using Pneumococ- 

 cus Vaccine was McDonald, who produced arti- 

 ficial crises in rabbits by inoculating them with 

 a vaccine after they had been infected with the 

 pneumococcus. He was able to produce a crisis 

 and recovery at w.ill, and the control rabbits on 

 whom the vaccine was not used died. Harris 

 states that Pneumococcus Vaccine in the seque- 

 lae of pneumonia and other pneumococcus infec- 

 tions is as sure as Staphylococcus Vaccine in 

 boils! According to Leary, the crisis in pneu- 

 monia under vaccine treatment occurs earlier, 

 the course of the disease is favorably influenced, 

 and there is marked relief from the toxic symp- 

 toms. Vaccines are of value in delayed resolu- 

 tion of the consolidated lung in which there is 

 but little remnant of the original general infec- 

 tion. 



Results of Vaccine Treatment The effect of 

 the initial dose should be watched to decide the 



