VACCINES IN TREATMENT OF DISEASE 279 



time of repetition. If the temperature rises 

 from one to three degrees, it will be safest to 

 give no more vaccine during 24 hours. In 

 America, Stoner has reviewed the results ob- 

 tained in 155 cases of pneumonia treated by 

 means of Pneumococcus Vaccine, with a mortal- 

 ity of 13 per cent. Inasmuch as the average 

 mortality statistics in pneumonia range from 

 20 to 25 per cent, these figures indicate a 

 marked reduction in the death rate. 



In the more chronic forms of pneumococcus 

 infection of the lungs, such as delayed resolu- 

 tion and empyema, it would seem from the ex- 

 perience of Wright that a combined vaccine 

 should be used. 



Clinical Reports In the treatment of pneu- 

 monia, it is essential that the vaccine be admin- 

 istered early in the disease. Improvement usu- 

 ally occurs within 24 hours after the first in- 

 jection : the crisis occurs earlier and the dura- 

 tion of the disease is lessened under the vac- 

 cine treatment. Major Bispham of the United 

 States Army reported 19 cases of pneumonia, 

 six of which were treated symptomatically with 

 two deaths, while the remaining 13 cases were 

 treated with Pneumococcus Vaccine with no 



