284 MODERN BIOLOGIC THERAPEUSIS 



combined vaccine is usually given every second 

 day, but some clinicians now advise, especially 

 in severe cases, that the doses be administered 

 daily. The practitioner must be guided mainly 

 by the number and severity of the paroxysms in 

 giving the vaccine. It is recommended that the 

 combined vaccine be given every two or three 

 days in doses containing from 12i/> million to 

 100 million each of the Bordet bacillus, influenza 

 bacillus, pneumococcus, streptococcus and sta- 

 phylococcus, according to the age of the child 

 and the severity of the disease. It is advisable, 

 especially in babies and young children, to ad- 

 minister a small initial dose containing 12 ^ 

 million of each of the above-named bacteria, and 

 this dose may be gradually or rapidly increased 

 as symptoms may indicate. According to the 

 published reports, it seems perfectly safe to 

 give an initial dose of 25 million of each of the 

 foregoing bacteria to a child over two years of 

 age, subsequent doses being made larger accord- 

 ing to the requirements of the individual case. 

 Clinical results seem to indicate that the vac- 

 cine given in fairly large or ascending doses 

 brings about a more rapid cure than smaller 

 doses of constant size. The duration of whoop- 



