290 MODERN BIOLOGIC THERAPEUSIS 



ed with vaccines. There was a mortality of 4.6 

 per cent. He concludes: (1) Inoculations of 

 vaccine in typhoid fever prevent relapses and 

 lessen complications and, in some cases, prob- 

 ably shorten the original attack. (2) In thera- 

 peutic doses, such vaccines are without injuri- 

 ous effect and do not interfere with other treat- 

 ment. 



Dosage It has been estimated that the num- 

 ber of cases of typhoid fever in the United 

 States is now about 150,000 annually and the 

 deaths approximately 25,000, or 16.5 per cent. 

 Hence, the mortality reported by Waiters and 

 by Callison is a decrease of three-fourths of the 

 usual mortality. 



The dosage of the vaccine varies considerably 

 with different observers. For example, Semple 

 used doses of 50 to 200 million ; Smallman used 

 doses of 100 to 300 million ; Hollis used doses of 

 10 to 250 million; Callison used initial doses of 

 100 to 300 million and recommended that subse- 

 quent doses be increased by 100 million; and 

 Meakins and Foster used doses of 1,000 to 2,000 

 million. Most of these authors have felt con- 

 vinced that patients treated with vaccine suf- 

 fered less depression, had lower temperatures, 



