180 PAPAIN-PROTEOLYSIS. 



ing bodies of animal origin ? Obviously, in considering this 

 question little weight can be attached to results obtained with 

 such products as Witte's so-called peptone, since the latter, 

 as is well known, is a mixture of several albumoses with 

 some peptone. Hence, the earlier results obtained with pro- 

 ducts in which the two classes of substances albumoses 

 and peptones were not differentiated have in the present 

 connection only a general interest.* Pollitzer,f on the other 

 hand, working with the individual albumoses formed by pep- 

 sin-acid, found that while all of these substances prevented 

 or delayed the coagulation of the blood, the primary albumoses 

 were most effective, deuteroalbumose least so. Further, am- 

 phopeptone led to variable results, frequently wholly negative, 

 while antipeptone as formed by trypsin was almost entirely 

 wanting in any constant effects. Grosjean,J however, ob- 

 served that the peptone formed in gastric digestion does 

 retard coagulation, although its action is less vigorous than 

 that of the albumoses. With antipeptone, Spiro and Ellinger 

 found that the effect produced was dependent entirely upon 

 the dosage of peptone employed. Thus, with 0.6 gram per 

 kilo of body-weight coagulation-time was reduced from eight 

 to four minutes, while with 1.1 grams of peptone per kilo the 

 blood was rendered non-coagulable. Lastly, Thompson || has 



* Schmidt-Miilheim, Beitrage zur Kenntniss des Peptons und seiner phys- 

 iologischcn Bedeutung. Du Bois-Reymond's Archiv f . Physiol., 1880, p. 33 ; 

 Fano, Das Verhalten des Peptons und Tryptons gegen Blut und Lymphe. 

 Ibid., 1881, p. 277 ; Thompson, Contribution to the Physiological Effects of 

 " Peptone " when Injected into the Circulation. Journal of Physiology, 1896, 

 xx, p. 455. 



t Pollitzer, On the Physiological Action of Peptones and Albumoses. 

 Ibid., 1886, vii, p. 283. 



t Grosjean, Recherches sur 1'action physiologique de la propeptone et de 

 la peptone. Archives de biologic, 1892, xii. 



Spiro and Ellinger, Der Antagonismus gerinnungsbefordernder und 

 gerinnungshemmender Stoffe im Blute und die sogenannte Peptonimmunitat. 

 Zeitschr. f. physiol. Chem., 1897, xxiii, p. 135. 



(I Thompson, The Physiological Effects of Peptone and its Precursors when 

 introduced into the Circulation. Interim Report of a Committee consisting of 

 Professors Schafer, Sherrington, Boyce, and Thompson. Report by the Sec- 

 retary, 1896-97. 



