PAPAIN-PROTEOLYSIS. 185 



gradually but steadily, and in ten minutes from the time of 

 injection was approximately normal again. 



A dog of 11.6 kilos, under chloroform-ether narcosis, was 

 treated with 5.6 grams of the albumose by injection into the 

 femoral vein, the injection lasting 45 seconds. Here, the 

 pressure fell from about 150 mm. Hg to 100 mm. within one 

 minute, gradually rising again to the normal in about seven 

 minutes. In this experiment the fall of pressure was preceded 

 by a slight rise, amounting to 5 mm. This initial effect of the 

 injection of deuteroalbumose upon blood-pressure, i. e. a slight 

 rise, is in harmony with the observations of Thompson* with 

 Witte's " peptone." 



Similar experiments with pure papain-peptone gave corre- 

 sponding results, namely, an immediate and rapid fall of pres- 

 sure, the latter rising to the normal again in nine to twelve 

 minutes. 



* Thompson, loc. cit., p. 461. 



