208 INFLUENCE OF BILE AND BILE SALTS 



in Experiments 2 and 7, also in 12 and 13. Here we have 

 marked differences in the ratio of acid salts to alkaline salts, 

 but without any appreciable difference in the relative pro- 

 teolytic action of the mixtures. Everything else being equal, 

 we should expect to find increased proteolysis most marked in 

 those mixtures where the bile introduced showed a predomi- 

 nance of alkaline salts, but no such conclusion can be drawn 

 from the results. On the contrary, it is plain that such slight 

 influence as bile exerts on the proteolytic action of neutral 

 pancreatic juice is not connected primarily with change 

 of reaction, but must be attributed to some other cause. 

 These points, however, will be referred to again in another 

 connection. 



HI. INFLUENCE OF FRESH BILE ON THE PBOTEOLYTIC 

 ACTION OF THE PANCREATIC ENZYME IN ALKALINE 

 SOLUTION. 



The experiments embraced under this head were conducted 

 in the same manner as those previously described, except that 

 to each digestive mixture was added 0.125 gram of sodium 

 carbonate. Hence, each mixture contained 0.25 per cent 

 sodium carbonate, unless modified by the bile added. Follow- 

 ing are the results obtained : 



Experiment 18. Fig's bile. Alkaline extract of ox pancreas. 



Per cent of Bile. Undigested Residue. Fibrin Digested. Relative Proteolytic Action. 



0.3721 gram 62.79 per cent 100.0 



0.3790 62.10 98.9 



1.0 0.4440 55.60 88.5 



1.0 0.4350 56.50 89.9 



2.0 0.4490 65.10 87.7 



2.0 0.4699 53.01 84.4 



6.0 0.4318 66.82 90.4 



6.0 0.4230 67.70 91.8 



10.0 0.4255 67.45 91.4 



10.0 0.4198 58.02 92.4 



