ON PANCREATIC PROTEOLYSIS. 



223 



What, now, is the influence of bile and bile salts on pan- 

 creatic proteolysis in the presence of combined acid? The 

 answer to this question is found in the results of the follow- 

 ing experiments : 



Ox-bile salts. 



Experiment 47. With extract of ox pancreas. 

 Character of the Fluid. 



Neutral 



" -f 2% Bile salts 



" +4% " 



Proteids combined with acid 

 Eighth saturated with acid (0.005% HC1) 

 " " " + 2% Bile salts 



Quarter " " (0.01% HC1) 



" + 2% Bile salts 

 " +4% " 



Experiment 48. With extract of pig's pancreas. Bile salts from pig's bile. 

 CharacteroftheFluid. S* Jg& $& 



Neutral 



Proteids combined with HC1 

 Half saturated with acid (0.013% HC1) 

 " " " + 0.5% Bile salts 



+ 1.0% 



" " " + 2.0% " 



" " " + 3.0% " 



grm. 

 0.1755 



0.2337 

 0.4433 

 0.4039 

 0.4958 

 0.4992 



per cent. 



82.45 100.0 



76.63 92.9 



55.67 67.5 



59.61 72.2 



50.42 61.1 



60.08 60.7 



Experiment 49. With extract of pig's pancreas. Bile salts from pig's bile. 

 The salts somewhat acid in reaction. Salicylic acid used to combine with 

 the proteids. 



Character of the Fluid. 



Undigested Fibrin 

 Residue. Digested. 



grm. 



Neutral 0.3041 



" +3% Bile salts 0.6338 



Proteids combined with acid 



Wholly saturated with acid (0.064% acid) 0.6795 

 + 3% Bile salts 

 (0.032% acid) 

 " +3% Bile salts 



Half 



Quarter 



(0.016% acid) 

 + 3% Bile salts 



0.7608 

 0.4296 

 0.6773 

 0.3608 

 0.5591 



per cent. 

 69.69 

 46.62 



42.05 

 23.92 

 67.04 

 32.27 

 63.92 

 44.09 



Action. 

 100.0 



66.9 



60.4 

 34.3 

 81.9 

 46.3 

 91.8 

 63.3 



