252 



ON THE EXCRETION OF 



The increased output of kynurenic acid attending the large 

 increase in proteid katabolism (over that in inanition) thus 

 justifies the emphasis placed upon the close relationship 

 between these factors. Owing to less careful conditions of 

 experiment (lack of catheterization, etci) the ratio of dextrose 

 to nitrogen is somewhat lower than that found by Lusk. In 



FIGURE 1. 



DOG K. The abscissae represent the successive days of the experiment ; the 

 ordinates of the unbroken line represent grams of N excreted, those of the 

 broken line represent milligrams of kynurenic acid. 



the experiment on Dog K the ratio is higher. In this animal 

 sugar persisted in the urine for several days after the phlo- 

 rhizin injection. The ratio of dextrose to nitrogen during the 

 phlorhizin days was as 3.68: 1. The other phenomena 

 observed resemble those of the preceding experiment, namely, 

 increased kynurenic acid excretion accompanying stimulated 

 proteid decomposition,* as shown in the curves of Fig. 1. 



Amyl nitrite experiment. The production of diabetes in the 

 dog by means of amyl nitrite has been demonstrated by a 

 number of investigators, f We have also studied the action of 



In the case of one dog which excreted no kynurenic acid during six 

 days' starvation we were unable to get similar results with phlorhizin. 



t Araki, Zeitschr. f. physiol. Chemie, 1891, xv, p. 663. The older literature 

 is referred to here. 



