286 A CHEMICO-PHYSIOLOGICAL STUDY OF 



workers (Pollitzer, Spiro, and Ellinger*) Thompson found 

 that antipeptone contrasts very noticeably with the other pro- 

 ducts of proteid digestion studied in its action on blood- 

 pressure. The fall of pressure produced was temporary at 

 most. 



Our experiments on blood-pressure, the results of which are 

 summarized in the following table, indicate that antialbumid, 

 a product whose physiological action has not heretofore been 

 investigated, agrees with the antipeptone derived from it in 

 producing comparatively slight effects on mean arterial pres- 

 sure. In like doses, however, antialbumid is somewhat more 

 vigorous in action than antipeptone. Further, it is evident 

 that antipeptone derived from antialbumid produces essentially 

 the same results as antipeptone formed by the direct action of 

 pancreatic juice on a natural proteid. Antialbumoses, on the 

 other hand, act most energetically in lowering blood-pressure. 

 In no case was a return of mean arterial pressure to the normal 

 observed within an hour after injection of the various albu- 

 moses studied. The same was true of the hemialbumoses. 

 The albumoses of different origin act qualitatively and quanti- 

 tatively alike in great degree, heteroalbumose being apparently 

 most vigorous in its effects. This corresponds with the obser- 

 vations of Pollitzer,f and we are inclined to attribute the 

 pronounced effects produced by Witte's " pepton " to the con- 

 siderable admixture of heteroproteose, which it has repeatedly 

 been shown to contain.^: 



Our experiments with hemipeptone agree with the results 

 obtained by Grosjean and later by Thompson with amphopep- 

 tone isolated by Kiihne's method. Further, between hemipep- 

 tone and antipeptone there is little or no difference of action 

 when like amounts of substance are employed. It is interest- 

 ing, however, to contrast the action of equal doses of hemi- 

 peptone (XIX-XX) with that of the hemialbumoses (V) from 

 the same source. It is only with doses of 1.0 gram of hemi- 



* Spiro and Ellinger, Zeitschr. f. physiol. Chem., 1897, xxiii, p. 136. 



t Pollitzer, loc. cit. 



t Kiihne and Chittenden, Zeitschr. f. Biologic, 1884, xx, p. 15. 



