296 A CHEMICO-PHYSIOLOGICAL STUDY OF 



(3) Both hemi- and antipeptone when introduced into the 

 circulation in doses up to 0.5 gram per kilo cause no retarda- 

 tion or even acceleration of coagulation. Larger doses of 

 hemipeptone * (1 gram per kilo), however, act more like 

 the albumoses. (Exper. XXII.) 



(4) Protogelatose, as formed by gastric digestion, tends to 

 hasten coagulation even when introduced in large doses, f 

 Large doses of deuterogelatose retard coagulation quite notice- 

 ably, our results agreeing in a general way with the observa- 

 tions made by Arthus and Huber J with mixed gelatoses and 

 gelatin-peptone. True gelatin-peptone entirely free from 

 gelatoses tends to accelerate slightly the coagulation of the 

 blood. 



Independence of arterial pressure and coagulation phenomena. 

 The results of the present experiments lend weight to the 

 view that the characteristic fall of arterial pressure and the 

 accompanying lack of coagulability are entirely independent 

 phenomena. The former is doubtless due to a direct and 



creatic digestion, some peculiar results were obtained which are not included 

 in our table. Thus, in one experiment a dog weighing 5.2 kilos received an 

 injection of 25 c.c. of a solution of this antialbumid in weak ammonia (con- 

 taining 0.29 gram of the dry antialbumid). Three blood samples taken before 

 the injection clotted in two minutes, and arterial pressure stood at 90 mm. of 

 mercury. One minute after the injection blood-pressure fell to 10 mm. and 

 two minutes later the animal was dead. The heart and larger blood vessels 

 were opened and the blood was found to be clotted solid. A like result was 

 obtained with another dog of the same body-weight, by using a somewhat 

 larger dose of the antialbumid, namely 0.58 gram. In a third experiment, 

 with a dog of 13.6 kilos, using 0.35 gram of antialbumid as the total amount 

 injected, there was a marked fall of arterial pressure, but no effect on blood 

 coagulation. Lastly, with a fourth dog of 16 kilos having a cannula in the 

 thoracic duct, the injection of the antialbumid (0.29 gram in 26 c.c. fluid) led 

 to a fall of arterial pressure, a retardation of 10-12 minutes in the coagula- 

 tion of the blood, a cessation of the flow of urine from the kidneys, with a 

 small increase in the flow of lymph. 



Cf. the experiments on papa'in-peptone by Chittenden, Mendel, and 

 McDermott, Amer. Jour. Physiol. 1898, i, p. 271. 



t Cf. Dastre and Floresco, Archives de physiologic, 1896, p. 402; also 

 Floresco, Ibid., 1897, p. 777. 



t Arthus and Huber, Archives de physiologic, 1896, p. 857. 



With reference to the peculiar results obtained in Exper. XXXI see the 

 section on lymph. 



