CERTAIN DERIVATIVES OF THE PROTEIDS. 301 



to some degree of immunity is clearly shown by the fact that 

 the second fall of pressure is noticeably less than the first 

 one, and by the fact that the return of pressure to the normal 

 follows somewhat more rapidly than after the first injection. 

 Our results thus confirm, in part, Grosjean's observations, 

 and extend them by demonstrating that the immunity ac- 

 quired is by no means characteristic of specific products 

 injected, but rather due to a specific reaction produced in 

 each case within the organism itself. Delezenne* has ar- 

 rived at a similar conclusion from quite different observations. 

 Lastly, Dastre and Floresco f have recently shown that the 

 power of conferring immunity to "peptone" injections is 

 common to a large number of substances, i. e., urine, bile, 

 salts of iron, calcium chloride, etc. 



Influence on lymph-flow, etc. Since Heidenhain's $ mas- 

 terly researches on the action of lymphagogues there has 

 been, so far as we recall, no attempt to compare the lympha- 

 gogic action of the individual proteoses and peptones. It is 

 well known that various substances which prevent clotting of 

 the blood simultaneously increase the flow of lymph from the 

 thoracic duct ; the substances studied, however, have been for 

 the most part merely extracts of various organs and tissues 

 (leech-extract, extracts of crayfish and mussels). A system- 

 atic study of the active constituents of these extracts would 

 be of great interest. 



The following table contains the results of several of our 

 experiments on the action of certain specific proteid and al- 

 buminoid derivatives on the flow and composition of the 

 lymph. All the animals experimented on were dogs, and 

 were deprived of food for 24-36 hours prior to the experiment. 



The results of our experiments justify the following 

 conclusions : 



(1) Antialbumid, hemipeptone, heteroalbumose, and deu- 

 terogelatose may act as true lymphagogues. This is demon- 



* Delezenne, Archives de physiologic, 1897, pp. 657-659. 



t Dastre and Floresco, Comptes rendus de la Soc. de Biologie, 1898. p. 457 



J Heidenhain, Archiv f. d. ges. Physiol., 1891, xlix, p. 216. 



