CERTAIN DERIVATIVES OF THE PROTEIDS. 305 



hand, as already pointed out, heteroalbumose stimulates in 

 marked degree the flow of lymph. (See preceding table on 

 lymph-flow.) 



Antialbumid acts much like ordinary albumoses in checking 

 the secretion of urine, but if comparison is made, by reference 

 to the table showing arterial pressure, of the influence on renal 

 secretion and mean arterial pressure, as in Experiments VIII, 

 X, and XI, it will be seen that the inhibitory effect on the 

 secretory action of the kidneys is considerably greater than 

 would naturally be expected from the short period of dimin- 

 ished arterial pressure. This fact obviously suggests a specific 

 action on the part of antialbumid upon the kidneys independent 

 of pressure. 



On the other hand, large doses of hemipeptone, protogelatose, 

 and deuterogelatose have a marked diuretic effect, increasing 

 not only the volume of urine secreted in a given time, but 

 likewise the content of solid matter, as shown by the very- 

 decided increase in specific gravity.* Coincident with the 

 diuresis it will be observed that mean arterial pressure is 

 slightly raised under the influence of the substance. The 

 marked rise in the specific gravity of the urine, noticed after 

 the injections, is associated mainly with the rapid excretion of 

 the substance thrown into the circulation. As has been pre- 

 viously noted f in this connection, a primary proteose intro- 

 duced into the blood is eliminated, in part at least as a secondary 

 proteose. In other words, the primary body undergoes hydra- 

 tion in the kidney $ or elsewhere, and is excreted through the 

 urine in slightly altered form. Thus, in Experiment XXIV 

 with protogelatose not only was the rate of flow of the urine 

 more than doubled, but the specific gravity rose from 1021 to 

 1061. Examination of the urine showed the presence of a 

 large amount of gelatose, but this was mainly deuterogelatose. 



* See Chittenden, Science, N. S. v, June 11, 1897, p. 902; also Thompson, 

 Journal of Physiology (Proceed. Physiol. Soc.), 1898, xxii, p. xi. 



t Neumeister, Zeitschr. f. Biologic, 1887, xxiv, p. 272 ; also Chitten- 

 den, Mendel, and McDermott, Amer. Jour. Physiol., 1898, i, p. 266. 



t Neumeister, loc. cit. 



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