340 



OBSERVATIONS ON THE NITROGENOUS 



periods ; the animals were allowed water ad libitum and they 

 discharged their urine with considerable regularity. The 

 collections were made daily, and it was found that the results 

 thus obtained with different diets during periods of several 

 days were sufficiently pronounced to afford definite conclu- 

 sions. Extracts from protocols will be found in Tables 

 I-VII. 



EXPERIMENT HI. 



Two cats were employed. The diet consisted of the same foods as in the 

 preceding experiment. The pancreas fed was fresh, lean, sheep's pancreas. 



The experiments recorded suffice to demonstrate the ready 

 production of uric acid after ingestion of foods rich hi nuclein 

 substances, e. g., thymus and pancreas. The persistence of 

 a high uric acid excretion frequently on the day following 

 the feeding of the glands is doubtless hi part due to the 

 method employed in collecting the urine (lack of catheteriza- 

 tion) rather than to any characteristic after-effect of the diet. 

 The results show so complete an analogy with the similar 

 feeding experiments on man and on the dog,f that detailed 



* Part of the food rejected on this and the following day. 



t For references to the literature on thymus and pancreas feeding see : 

 (man) Huppert, loc. cit., p. 313; Th. Cohn, Zeitschrif t f iir physiol. Chemie, 

 1898, xxv, p. 609 ; Hopkins and Hope, Journal of Physiology, 1898, xxiii, p. 

 271; Weiss, Zeitschrift fiir physiol. Chemie, 1899, xxvii, p. 216; Jerome 



